Lotusphere 2006 was my first, and I definitely learned what to do differently. If you can learn from my pain, I'll gladly share my experience.
First, do what others have suggested: plan your session list well ahead. Always gives yourself alternates. Ben's sessions database is great for that because it shows you everything in the same time slot.
Second, plan smart. Last year I didn't realize that the Swan and Dolphin are so far apart, or that getting from DL S Hem 1 to SW 1 is about half a mile. Here are the floorplans: http://www.swandolphinmeetings.com/space/floorplans.html
Third, dress for comfort. Good WALKING shoes are a must!! You will be walking at least a couple of miles a day. Keep in mind that Orlando's average high in January is 72 (but they did have a record low of 26 during Lotusphere 2003). Just keep an eye on the weather and plan accordingly. Last year I nearly froze to death in some of the sessions so I'm bringing a light jacket I can stuff into my backpack.
Fourth, PARTICIPATE! The presenters are people too so don't be afraid to talk to them. Talk to your fellow conference attendees. Don't eat lunch alone or just with your coworkers. Go to the BoF's and spend time in the labs. There is a whole lot more to Lotusphere than just running from session to session.
Have fun, and I'll see you there. :-)