I have logged a similar call with BugZilla. I have a Domino 8.5.2 FP1 server that I want to roll out iNotes on as I wish to use a mobile broadband VPN.
What I have found is if you start Firefox.exe -safe-mode and switch to "Lite Mode" it almost works as it should (the tabs above the email are not named when you open/create emails, however).
"Lotus need to create a support document for their users, explaining how to
whitelist sites for XUL use, until they finally remove the need for XUL from
iNotes / provide an update to users. This is something only IBM/Lotus can do
and you would need to chase them up via their own support channels."
iNotes 8.5.2, FireFox 4 final build, XUL
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. . . . iNotes 8.5.2, FireFox 4 final build... (Stephen Hogan 23.Mar.11) 
