Thanks for the quick reply, but not luck.
1) The conneciton document is set-up correctly, verified this on my machines. Plus, this is affecting all internal users and worked fine yesterday. :-/
2) Could only find one notes.ini file and will dig through it to see if I find anything odd. (I may just shut down the server and replace the NAB and the INI and see if that does anything, hopefully last nights back-up worked correctly)
3) When I do a command prompt ping and trace everything works correctly. When I run a trace from within the notes client I get a response like this:
Determining path to server SERVER1
Available Ports: TCPIP
Checking normal priority connection documents only...
Allowing wild card connection documents...
Checking for SERVER1 at last known address 'SERVER1.SERVER1.com' on TCPIP...
Unable to connect to SERVER1 on TCPIP (Remote system no longer responding)
No answer at last known address
Enabling name service requests and probes...
Requesting address of SERVER1 from SERVER2 on TCPIP
Using address '10.41.1.34' for SERVER2 on TCPIP
Address 'SERVER1.SERVER1.com' returned for SERVER1 on TCPIP
The server was not responding at this address
Unable to find any path to SERVER1 because Remote system no longer responding
No luck. All the configurations and set-ups look good to me. All our internal users are dead in the water right now, really weird.